Researchers at Indiana University have found early evidence that tiny snippets of genetic material called microRNA may help with early detection of conditions such as Alzheimer's disease.
The study, published June 18 in Nature Scientific Reports, found that changes in microRNA are detectable in mice long before they start to show symptoms from neurodegeneration. These microRNA changes may represent an early warning sign, or "biomarker," for the condition.
"Identifying biomarkers early in a disease is important for diagnosing the condition, and following its progression and response to treatment," said Hui-Chen Lu, a professor in the Linda and Jack Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, a part of the IU Bloomington College of Arts and Sciences, who led the study. "You need something that can predict your future."
There is currently no treatment to stop or reverse the effects of neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS or Huntington's. It's also estimated that Alzheimer's disease alone, which is the most common of these disorders, will affect 14 million Americans and cost taxpayers $1.1 trillion by 2050.
Unlike regular "messenger RNA," which direct cells to produce specific proteins, microRNA plays a regulatory role, increasing or decreasing the number of proteins that messenger RNAs encode. A single snippet of microRNA can impact the function of tens or hundreds of proteins in the body.
Due to their stability in urine and blood, there is growing interest in using microRNA as biomarkers for disease prediction and diagnosis. Lu's study is an early step to learn whether microRNA can be used to detect neurodegenerative disorders.
To explore this question, Lu and colleagues analyzed microRNA and messenger RNA in two groups: a healthy group and a group genetically modified to develop symptoms of dementia. The team found the highest level of "dysregulation" -- or deviation from normal levels -- in the microRNA of the dementia group before their physical symptoms developed.
"Higher levels of pre-symptomatic microRNA dysregulation are significant because it strongly suggests that it may have a role in changes in the brain in later stages," Lu said.
The team then compared the microRNA changes to the messenger RNA changes to identify biological pathways affected by microRNA dysregulation. Their analysis suggested that changes in microRNA affected pathways related to immunity in the dementia-prone model.
In response, the team then conducted additional tests to study a specific type of microRNA that was elevated in the dementia model. The microRNA -- called microRNA 142 -- is known to play a major role in inflammation, a part of the immune response.
They found that introducing this microRNA into the brain triggered a significant neuroinflammation. The result is important since many other studies have shown that chronic inflammation contributes to many types of disease, including neurodegeneration, Lu said.
She added that the next step will be to learn whether microRNA 142 is easily detectable through a blood test, a key quality for a truly non-invasive biomarker.
Purple is the official color of the Alzheimer's movement. Click here to see how you can "go purple" to help spread awarness about Alzheimer's. Being informed and sharing that info helps everyone by undestand how prevalant Alzheimer's is and how we can deal with it. Click on this link to learn several ways to spread the word and go purple.
Ideas to Celebrate Alzheimer's & Brain Awareness Month
Go purple at your school or office! Encourage your coworkers or students to wear purple on Monday, June 20. Decorate your breakroom or common area in purple. Hang some streamers and balloons. Post facts about Alzheimer's disease at your workplace, group meeting, or place of worship to raise awareness. Use and wear purple. Everyone loves a casual work day! Make sure to post your purple on social media using the hashtags #GOPURPLE and #ENDALZ.
You can use the following facts to spread awareness. And as always, turn to Mountain Home Care when you need assistance. Suggest us to those you know who are dealing with Alzheimer’s and Dementia in their families. We are here to help!
The number of Americans living with Alzheimer's is growing — and growing fast. An estimated 5.7 million Americans of all ages have Alzheimer’s.
Alzheimer's disease is the only top 10 cause of death in the United States that cannot be prevented, cured or even slowed.
Eighty-three percent of the help provided to older adults in the United States comes from family members, friends or other unpaid caregivers. Nearly half of all caregivers who provide help to older adults do so for someone with Alzheimer's or another dementia.
Teepa Snow does a great job in helping to remove confusion and bring understanding about the differences between Dementia and Alzheimer's. Watch her discuss what dementia actually is in the clip below. When you are ready for more information and need help with a personal family or loved one situation, contact us at Mountain Home Care. We are experts in the field and can guide you through the process.
Here are seven tips based on Teepa Snow’s Positive Approach to Care.
1) Learn more about the disease- Learn what it does and doesn't do and what it is going to mean for you. Everything changes and can be unpredictable.
2) See it as a journey- It's not a sprint, so plan for the longer journey ahead.
3) Don’t be a lone ranger- If you try to be you will run out of gas.
4) Learn “positive approach to care” skills. We can help with this.
5) Become a care partner instead of just a care giver. If you push help at someone they might push back. Learn to change when something isn't working.
6) Find resources. There is a lot of good info out there. We can also help you with this.
7) Learn the art of letting go...breathe! Take care of yourself, to take care of others.
Mountain Home Care is highly-trained in Teepa’s Positive Approach to Care and can help you navigate your way through this journey.